Ozone therapy involves the use of ozone (O₃) gas, which is an activated form of oxygen, to support various health conditions. Ozone is typically administered through different methods, such as intravenous (IV) infusions, rectal, or insufflation (administering gas via the body cavities). It has potential therapeutic benefits due to its ability to enhance oxygen delivery and stimulate the body’s natural healing mechanisms. Ozone therapy has gained attention within integrative oncology medicine as a supportive therapy for cancer care which is primarily used as a complementary or adjunctive therapy.
Improved Oxygen Delivery: Ozone therapy is thought to improve the oxygenation of tissues by increasing the availability of oxygen to cancer cells and surrounding healthy tissues. Cancerous tumours often suffer from hypoxia (low oxygen levels), which may affect their response to conventional treatments like chemotherapy and radiation. By improving oxygen delivery, ozone therapy may help these treatments work more effectively.
Immune System Stimulation: Ozone therapy is believed to stimulate the immune system. It may promote the production of cytokines and other immune-boosting agents, which could potentially help the body fight cancer cells. This immune stimulation may also reduce the risk of infection, which can be a concern for cancer patients undergoing oncology treatments.
Antioxidant Activity: Ozone therapy may trigger the body’s natural antioxidant defences, helping to neutralize harmful free radicals. This could reduce oxidative stress, which is often elevated in cancer patients.
Reduction of Tumour Size: Some studies suggest that ozone therapy may help reduce the size of tumours through the induction of oxidative stress in cancer cells. By increasing oxidative stress within the cancer cells, ozone therapy may cause the cells to become more vulnerable to treatments like chemotherapy or radiation.
Pain Reduction and Symptom Management: Ozone therapy has been reported to provide pain relief in some cancer patients, particularly those dealing with chronic pain due to the disease or treatment. By reducing inflammation and improving circulation, ozone therapy may help ease discomfort.
Detoxification: Ozone therapy may help with detoxification by promoting the elimination of toxins and metabolic waste products. This could be especially beneficial for cancer patients who have undergone chemotherapy, which often leads to an accumulation of toxins in the body.
Ozone therapy can be administered through various methods, each offering distinct benefits tailored to the patient’s condition, specific needs, and medical recommendations. The choice of administration method should always be individualized, considering the patient’s diagnosis, treatment goals, and response to therapy. Below are the most commonly used methods for ozone therapy in a clinical setting:
Autohemotherapy (Ozone IV Infusion): This is one of the most common forms of ozone therapy. In major autohemotherapy (MAH), a portion of the patient’s blood is drawn, mixed with ozone, and then reinfused back into the body. This process stimulates the immune system and enhances the body’s oxygen utilization.
Rectal and Vaginal Insufflation: In this procedure, ozone gas is introduced in a precisely calculated dose into the rectum and/or the vagina via a small catheter, where it is absorbed by the mucous membrane, triggering systemic effects. This method is widely used due to its convenience, safety and efficacy. These administration routs are of great convenience specially for cancer patients whose veins have suffered the effects of the chemotherapy. In addition to the systemic benefits (in the whole body), these administration routes are preferred when patients suffer from conditions in or next to these areas (such as candidiasis, ulcerative colitis, lesions in the cervix or in the colon/rectum or prostate, for example).
Subcutaneous injections/infiltrations: When a small amount of this gas is infiltrated into a targeted area such as the skin or the joints, the ozone can trigger a cascade of metabolic reactions stimulating anti-inflammatory reactions.
Precision and Safety: Like any medical treatment, ozone therapy requires careful dosing to ensure its benefits without causing harm. While ozone has demonstrated potential therapeutic effects in various conditions, its powerful oxidative properties mean that excessive doses can be toxic, leading to harmful side effects or exacerbating existing health issues. Ozone, when administered correctly, can yield remarkable improvements, but an incorrect or overly high dose may result in:
Ozone Toxicity: High concentrations of ozone can lead to oxidative damage in healthy cells, causing inflammation, cellular dysfunction, or even organ damage.
Damage to Blood Cells: Overexposure can affect red blood cells and the body’s ability to carry oxygen efficiently, exacerbating oxygen deprivation.
Excessive Oxidative Stress: The balance of oxidative and antioxidative processes is delicate. Too much ozone can lead to systemic oxidative stress, potentially affecting multiple organs and systems.
Individualized Approach to Dosing: Each patient’s condition, medical history, and specific needs must be considered when determining the right ozone dose. The goal is to provide enough ozone to stimulate healing processes—such as immune modulation, oxidative stress in cancer cells, and improved oxygen delivery—without crossing the threshold that could lead to toxicity.
Starting with Low Doses: In general, ozone therapy begins with low doses to assess tolerance and gradually increases the dose over time. This allows practitioners to monitor for any adverse reactions.
Tailoring the Treatment: Doses are adjusted based on factors such as the type of cancer, the patient’s overall health, response to therapy, and the specific method of administration (e.g., intravenous ozone, rectal or vaginal).
Avoiding “Standard Packages”: Offering a fixed “package” of ozone therapy sessions with a set number of passes or doses might not be suitable for every patient. Cancer treatment is highly individualized, and such one-size-fits-all approaches could ignore important factors such as disease progression, underlying conditions, and patient sensitivity.
Monitoring and Adjustments: Regular monitoring of the patient’s condition throughout ozone therapy is essential to track responses and make adjustments.
The administration of ozone therapy, especially in complex cases such as cancer care, requires highly skilled and knowledgeable practitioners who are well-versed in ozone’s safe application. Proper dosing, individualized treatment plans, and close monitoring are key factors in maximizing the therapy’s therapeutic effects while minimizing the risk of toxicity. As with any treatment, caution and professionalism are paramount to ensure the safety and efficacy of ozone therapy.
1. Bocci V, Paulesu L. Studies on the biological effects of ozone 1. Induction of interferon gamma on human leucocytes. Haematologica 1990; 75: 510-515.
2. Bocci V. Ozonization of blood for the therapy of viral diseases and immunodeficiencies. A hypothesis. Med Hypotheses 1992; 39: 30-34.
3. Paulesu L, Luzzi E, Bocci V. Studies on the biological effects of ozone: 2. Induction of tumor necrosis factor (TNF-ct) on human leucocytes. Lymphokine Cytokine Res 1991; 10: 409-412.
4. Bocci V, Luzzi E, Corradeschi F, Pauleso L, Di Stefano A. Studies on the biological effects of ozone: 3. An attempt to define conditions for optimal induction of cytokines. Lymphokine Cytokine Res 1993; 12: 121-126.
5. Bocci V, Luzzi E, Corradeschi F et al. Studies on the biological effects of ozone: 4. Cytokine production and glutathione levels in human erythrocytes. J Biol Regul Homeost Agent 1993; 7: 133-138.
6. Bocci V, Luzzi E, Corradeschi F, Paulesu L. Studies on the biological effects of ozone: 5. Evaluation of immunological parameters and tolerability in normal volunteers receiving ambulatory autohaemotherapy. Biotherapy 1994; 7: 83-90.
7. Bocci V, Luzzi E, Corradeschi F, Silvestri S. Studies on the biological effects of ozone: 6. Production of transforming growth factor 13by human blood after ozone treatment. J Biol Regul Homeost Agent 1994; 8:108-112.
8. Bocci V. Ozonetherapy today. In: Proceedings of the 12th Ozone World Congress, May 1995, Lille, France. Tours: Intaprint SA, 1995: 13-28.
9. Bocci V, Silvestri S, Corradeschi F, Sargentini I. Studies on the biological effects of ozone: 7) Induction of lipid peroxides during exposure of human blood to ozone. Med Sci Res 1995 (in press)
10. Viebahn R. The use of ozone in medicine. Heidelberg: Karl F. Haug Publishers, 1994: 178.
11. Wehrli F, Steinbart H. Erfahrungen mit der haematogenen Oxydations – Therapie (HOT). Ars Medici 1954; 10: 44-51. 12. Westermann J, Pabst R. Distribution of lymphocyte subsets and natural killer cells in the human body. Clin Invest 1992; 70: 539-544. 13. Westendorp M O, Shatrov V A, Schulze-OsthoffK et al. HIV-1 tat potentiates TNF-induced NF-kappa B activation and cyto- toxicity by altering the cellular redox state. EMBO J 1995; 14: 546-554.
14. Baeuerle P A, Henkel T. Function and activation of NF-kB in the immune system. Annu Rev Immunol 1994; 12: 141-179.
15. Anderson M T, Staal F JT, Gitler C, Herzenberg L A, Herzenberg LeA. Separation of oxidant-initiated and redox- regulated steps in the NF kB signal transduction pathway. Proc Natl Acad Sci USA 1994; 91: 11527-11531.
16. Mihm S, Gaiter D, Dr6ge W. Modulation of transcription factor NFnB activity by intracellular glutathione levels and by variations of the extraceUular cysteine supply. FASEB J 1995; 9: 246-252.
17. Roederer M, Staal FJT, Raju PA, Ela SW, Herzenberg LeA, Herzenberg L A. Cytokine-stimulated human immuno- deficiency virus replication is inhibited by N-acetyl-L- cysteine. Proc Natl Acad Sci USA 1990; 87: 4884-4888.
18. Kalebic T, Kinter A, Poll G, Anderson M E, Meister A, Fauci A S. Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine. Proc Natl Acad Sci USA 1991; 88: 986-990.
19. Bergamini A, Capozzi M, Ghibelli L et al. Cystamine potently suppresses in vitro HIV replication in acutely and chronically infected human cells. J Clin Invest 1994; 93:2251-2257.
20. Shoji S, Furuishi K, Misumi S, Miyazaki T, Kino M, Yamataka K. Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-l) production. Biochem Biophys Res Commun 1994; 205: 967-975.
21. Bocci V. A reasonable approach for the treatment of HIV infection in the early phase with ozonetherapy (autohemo- therapy). How inflammatory cytokines may have a therapeutic role. Mediat Inflamm 1994; 3: 315-321.
22. Halliwell B. How to characterize a biological antioxidant. Free Radic Res Commun 1990; 9: 1-32.
23. Meister A. Glutathione-ascorbic acid antioxidant system in animals. J Biol Chem 1994; 269: 9397-9400. 24. Yu BP. Cellular defenses against damage from reactive oxygen species. Physiol Rev 1994; 74: 139-162.
25. Cross C E, Reznick A Z, Packer L, Davis P A, Suzuki Y J, Halliwell B. Oxidative damage to human plasma proteins by ozone. Free Radic Res Commun 1992; 15: 347-352.
26. Halliwell B. Free radicals and antioxidants: a personal view. Nutr Rev 1994; 52: 253-265.
27. Beck N B, Koenig J Q, Luchtel D L, Altman L C, Orsborn M T, Kenney J S. Ozone can increase the expression of inter- cellular adhesion molecule- 1 and the synthesis of cytokines by human nasal epithelial cells. Inhal Toxicol 1994; 6: 345-357.
28. Dröge W, Mihm S, Bockstette Met al. Effect of reactive oxygen intermediates and antioxidants on proliferation and function of T lymphocytes. In: Methods in Enzymology, vol 234. New York: Academic Press, 1994:135-151.
29. McCord J M. Superoxide radical: controversies, contradictions, and paradoxes. Proc Soc Exp Biol Med 1995; 209:112-117.
30. Bocci V, Shallenberger F. Treatment of AID syndrome with ozonated major autohaemotherapy (MAH). In: Proceedings of the International Symposium on HIV and Cytokines. Paris: Inserm, 1995 (in press).
31. Frank L, Iqbal J, Hass M, Massaro D. New “rest period” protocol for inducing tolerance to high O2exposure in adult rats. Am J Physiol 1989; 257:L226-L231.
32. KaelinCM,ImMJ,MyersRAM,MansonPN,HoopesJE. The effects of hyperbaric oxygen on free flaps in rats. Arch Surg 1990; 125: 607-609. 33. Kindwall E P. Hyperbaric oxygen. BMJ 1993; 307: 515-516.
34. Kangasjärvi J, Talvinen J, Utriainen M, Karjalalnen R. Plant defence systems induced by ozone. Plant Cell Environ 1994; 17: 783-794.
35. Rosen D R, Siddique T, Patterson D et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993; 362: 59~2.
36. Toyokuni S, Okamoto K, Yodoi J, Hiai H. Persistent oxidative stress in cancer. FEBS Lett 1995; 358: 1-3.
37. Cohen S M, Olin K L, Feuer W J, Hjelmeland L, Keen C L, Morse L S. Low glutathione reductase and peroxidase activity in age-related macular degeneration. Br J Ophthalmol 1994; 78: 791-794.
38. Bondy SC. The relation of oxidative stress and hyper- excitation to neurological disease. Proc Soc Exp Biol Med 1995; 208: 337-345.
39. Gomez Moraleda M. Ozone therapy in the functional recovery from diseases involving damage to central nervous system cells. In: Proceedings of the 12th Ozone World Congress, May 1995, Lille, France. Tours: Intaprint SA, 1995:111-123.
40. Bocci V. Autohaemotherapy after treatment of blood with ozone. A reappraisal. J Int Med Res 1994; 22: 131-144.
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