Helleborus is a type of perennial plants in the family Ranunculaceae, with subtype Helleborus Niger (black hellebore) being of primary interest in both traditional and modern medicinal research.
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Historically, Helleborus has been used in traditional medicine for various ailments, including as a purgative for its purported ability to support certain cancers. More recently, extracts from Helleborus have gained attention in integrative medicine, with emerging research investigating the potential role in cancer.
Although Helleborus therapy is not yet widely accepted or well-studied in conventional oncology, it is gaining interest due to its possible anti-cancer properties. Much of the current scientific exploration of Helleborus is based on its bioactive compounds, which may exert anti-inflammatory, immunomodulatory, and even cytotoxic effects against cancer cells.
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The potential anti-cancer effects of Helleborus are attributed to several key bioactive compounds found in various species of the category. These include saponins, flavonoids, and alkaloids, which have been shown to possess anti-cancer, anti-inflammatory, and anti-metastatic properties. However, it is important to note that much of the current understanding of Helleborus anti-cancer effects is derived from preclinical research (cell line studies and animal models).
“What I appreciate medically about Helleborus therapy is its remarkably low incidence of contraindications across various forms of cancer. Beyond its broad compatibility, it supports immune function and may help manage symptoms caused by the cancer itself—such as systemic inflammation, lymphedema, ascites, and pleural effusion, among others—making it a vital component of an integrative treatment approach.”
Fiona
Diagnosis: Adenocarcinoma non-small cell lung cancer
Fiona was diagnosed with non-small cell lung cancer with bone metastases. After completing one session of chemotherapy and immunotherapy, she chose to discontinue further treatment due to the side effects she experienced. Fiona’s objective was to supplement her conventional treatment with an integrative approach. To facilitate this, she promptly provided us with her biopsy results for review, allowing us to design a tailored plan of integrative therapies to support her care. Throughout therapies at Wellbeing Medical Group, she received regular scans from her oncologist, who closely monitored her progress and showed great compassion and care. Fiona was able to successfully achieve her goal of maintaining both quality of life and disease stability.
Graeme
Diagnosis: Adenocarcinoma Oesophagus
Graeme first reached out to Wellbeing Medical Group while awaiting his final biopsy results and diagnosis. Determined to explore both NHS and private pathways, he aimed to secure the best outcomes for his upcoming treatments and surgery.
We collaborated closely with Graeme to develop an integrative care plan tailored to his needs, aligning with his NHS treatment strategy. Graeme’s goals included enhancement of his overall well-being, creating an anti-cancer effect and support towards adverse reactions/side effects to hospital treatment pathways.
Isis
Diagnosis: Hodgkin Lymphoma
Isis approached Wellbeing Medical Group upon receiving her cancer diagnosis, with no conventional treatment having yet commenced. Due to the aggressive nature of her condition, she was about to begin a six-month chemotherapy regimen. Isis’ objective was to integrate complementary therapies alongside her chemotherapy, aiming to mitigate side effects and enhance the effectiveness of the chemotherapy. Given the advanced stage of her diagnosis, Wellbeing Medical Group recommended a more aggressive integrative approach. Isis committed to a comprehensive protocol that included the incorporation of additional anti-cancer therapies to maximize her outcomes throughout her chemotherapy journey. Isis also dedicated several months to expanding her knowledge by engaging with a range of academic literature and research materials.
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Some studies suggest that Helleborus extracts may suppress tumour growth by interfering with various cellular pathways that cancer cells use to proliferate. These compounds may inhibit enzymes involved in cell division and reduce the expression of growth factors like vascular endothelial growth factor (VEGF), which is responsible for angiogenesis (formation of new blood vessels) that feeds tumour growth.
Anti-Inflammatory Effects: Chronic inflammation is a known risk factor for many types of cancer. Helleborus contains anti-inflammatory compounds that may help modulate the immune system and reduce inflammation in the tumour microenvironment. This may prevent tumour promotion and progression.
Research has shown Helleborus may possess the ability to inhibit cell migration and reduce the ability of cancer cells to invade new tissues. This effect is particularly relevant in cancers prone to metastasis, such as breast, prostate, and lung cancer.
Helleborus extracts may stimulate the immune system by enhancing the activity of immune cells. These immune cells play a central role in recognising cancer cells.
Cancer cells often have elevated levels of oxidative stress, which can contribute to their growth and survival. Helleborus compounds contain antioxidant properties that may help neutralise free radicals, thereby supporting healthy cells and promoting overall cellular health.
While Helleborus therapy holds potential as an adjunctive or supportive treatment in cancer care, its application remains in study at this stage. The available preclinical evidence suggests that Helleborus may have anti-cancer, anti-inflammatory, and immune-modulating properties that may complement traditional cancer treatments.
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