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Learn MoreHelleborus is a type of perennial plants in the family Ranunculaceae, with subtype Helleborus Niger (black hellebore) being of primary interest in both traditional and modern medicinal research. Historically, Helleborus has been used in traditional medicine for various ailments, including as a purgative for its purported ability to support certain cancers. More recently, extracts from Helleborus have gained attention in integrative medicine, with emerging research investigating the potential role in cancer.
Although Helleborus therapy is not yet widely accepted or well-studied in conventional oncology, it is gaining interest due to its possible anti-cancer properties. Much of the current scientific exploration of Helleborus is based on its bioactive compounds, which may exert anti-inflammatory, immunomodulatory, and even cytotoxic effects against cancer cells.
Mechanism of Action
The potential anti-cancer effects of Helleborus are attributed to several key bioactive compounds found in various species of the category. These include saponins, flavonoids, and alkaloids, which have been shown to possess anti-cancer, anti-inflammatory, and anti-metastatic properties. However, it is important to note that much of the current understanding of Helleborus anti-cancer effects is derived from preclinical research (cell line studies and animal models).
Benefits of Helleborus IV Infusion Therapy
Some studies suggest that Helleborus extracts may suppress tumour growth by interfering with various cellular pathways that cancer cells use to proliferate. These compounds may inhibit enzymes involved in cell division and reduce the expression of growth factors like vascular endothelial growth factor (VEGF), which is responsible for angiogenesis (formation of new blood vessels) that feeds tumour growth.
Anti-Inflammatory Effects: Chronic inflammation is a known risk factor for many types of cancer. Helleborus contains anti-inflammatory compounds that may help modulate the immune system and reduce inflammation in the tumour microenvironment. This may prevent tumour promotion and progression.
Research has shown Helleborus may possess the ability to inhibit cell migration and reduce the ability of cancer cells to invade new tissues. This effect is particularly relevant in cancers prone to metastasis, such as breast, prostate, and lung cancer.
Helleborus extracts may stimulate the immune system by enhancing the activity of immune cells. These immune cells play a central role in recognising cancer cells.
Cancer cells often have elevated levels of oxidative stress, which can contribute to their growth and survival. Helleborus compounds contain antioxidant properties that may help neutralise free radicals, thereby supporting healthy cells and promoting overall cellular health.
Summary
While Helleborus therapy holds potential as an adjunctive or supportive treatment in cancer care, its application remains in study at this stage. The available preclinical evidence suggests that Helleborus may have anti-cancer, anti-inflammatory, and immune-modulating properties that may complement traditional cancer treatments.
Research
Helleborus References:
1. Büssing A, Schweizer K. Effects of a phytopreparation from Helleborus niger on immunocompetent cells in vitro. Journal of Ethnopharmacology 1998;59(3): 139-146.
2. Büssing A, Suzart K, Pfüller U, Schweizer K. Immunomodulatory properties of Helleborus niger. 6th Interscience World Conference on Inflammation, Antirheumatics, Analgetics, Immunomodulators. 28-30 March 1995, Palexpo, Geneva, Switzerland 1995.
3. Schink M, Garcia-Käufer M, Bertrams J, Duckstein SM, Müller MB, Huber R, Stintzing FC, Gründemann C. Differential cytotoxic properties of Helleborus niger L. on tumour and immunocompetent cells. Journal of Ethnopharmacology 2015;159:129-136
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