- Targeting cancer vulnerabilities with high-dose vitamin C
Bryan Ngo et al. Nat Rev Cancer. 2019 May;19(5):271-282.
- The effect of ascorbic acid over the Etoposide- and Temozolomide-mediated cytotoxicity in Glioblastoma cell culture: a molecular study
Gokturk D, Kelebek H, Ceylan S, Yilmaz DM. Turk Neurosurg. 2018;28(1):13–8.
- High dose parenteral Ascorbate inhibited pancreatic Cancer growth and metastasis: mechanisms and a phase I/IIa study
Polireddy K, Dong R, Reed G, Yu J, Chen P, Williamson S, et al. Sci Rep. 2017;7(1):17188.
- Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice
Chen Q, Espey MG, Sun AY, Pooput C, Kirk KL, Krishna MC, et al. Proc Natl Acad Sci. 2008;105(32):11105–9.
- O2·− and H2O2 Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate
Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer Morales KL, Furqan M, et al. Cancer Cell. 2017;31(4):487–500.e8.
- High dose intravenous vitamin C improves quality of life in cancer patients
Takahashi H, Mizuno H, Yanagisawa A. Pers Med Universe. 2012;1(1):49–53.
- Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany
Vollbracht C, Schneider B, Leendert V, Weiss G, Auerbach L, Beuth J. In Vivo. 2011;25(6):983–90.
- Changes of terminal Cancer patients’ health-related quality of life after high dose vitamin C administration
Yeom CH, Jung GC, Song KJ. J Korean Med Sci. 2007;22(1):7.
- Ascorbate regulates haematopoietic stem cell function and leukaemogenesis
Agathocleous M, Meacham CE, Burgess RJ, Piskounova E, Zhao Z, Crane GM, et al. Nature. 2017;549(7673):476–81.
- Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism
Bonilla‐Porras AR, Jimenez‐Del‐Rio M, Velez‐Pardo C. Cancer Cell Int. 2011;11(1):19.
- Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin GH, Wang J, et al. Cell. 2017;170(6):1079–1095.e20.
- Vitamin C stabilizes CD8+ iTregs and enhances their therapeutic potential in controlling murine GVHD and leukemia relapse
Iamsawat S, Tian L, Daenthanasanmak A, Wu Y, Nguyen HD, Bastian D, et al. Blood Adv. 2019;3(24):4187–201.
- Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia
Mingay M, Chaturvedi A, Bilenky M, Cao Q, Jackson L, Hui T, et al. Leukemia. 2018;32(1):11–20.
- Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer
Aguilera O, Muñoz‐Sagastibelza M, Torrejón B, Borrero‐Palacios A, del Puerto‐Nevado L, Martínez‐Useros J, et al. Oncotarget. 2016;7(30):47954–65.
- Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells
Brandt KE, Falls KC, Schoenfeld JD, Rodman SN, Gu Z, Zhan F, et al. Redox Biol. 2018;14:82–7.
- Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer
Cenigaonandia‐Campillo A, Serna‐Blasco R, Gómez‐Ocabo L, Solanes‐Casado S, Baños‐Herraiz N, Del Puerto‐Nevado L, et al. Theranostics. 2021;11(8):3595–606.
- Cytotoxicity of ascorbic acid in a human colorectal adenocarcinoma cell line (WiDr): in vitro and in vivo studies
Mamede AC, Pires AS, Abrantes AM, Tavares SD, Gonçalves AC, Casalta‐Lopes JE, et al. Nutr Cancer. 2012;64(7):1049–57.
- High-dose vitamin C exerts its anti-cancer effects in a Xenograft model of Colon Cancer by suppressing angiogenesis
Nakanishi K, Hiramoto K, Ooi K. Biol Pharm Bull. 2021;44(6):884–7.
- Ascorbic acid and colon cancer: an oxidative stimulus to cell death depending on cell profile
Pires AS, Marques CR, Encarnação JC, Abrantes AM, Mamede AC, Laranjo M, et al. Eur J Cell Biol. 2016;95(6–7):208–18.
- In vitro and in vivo assessment of high-dose vitamin C against murine tumors
Wang G, Yin T, Wang Y. Exp Ther Med. 2016;12(5):3058–62.
- Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, et al. Science. 2015;350(6266):1391–6.
- High-dose vitamin C administration inhibits the invasion and proliferation of melanoma cells in mice ovary
Nakanishi K, Hiramoto K, Sato EF, Ooi K. Biol Pharm Bull. 2021;44(1):75–81.
- Vitamin C induces human melanoma A375 cell apoptosis via Bax- and Bcl-2-mediated mitochondrial pathways
Chen XY, Chen Y, Qu CJ, Pan ZH, Qin Y, Zhang X, et al. Oncol Lett. 2019;18(4):3880–6.
- L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathway
Kang JS, Cho D, Kim Y-I, Hahm E, Yang Y, Kim D, et al. Cancer Immunol Immunother. 2003;52(11):693–8.
- Ascorbate induces apoptosis in melanoma cells by suppressing Clusterin expression
Mustafi S, Sant DW, Liu Z-J, Wang G. Sci Rep. 2017;7(1):3671.
- Antitumor effect of pharmacologic ascorbate in the B16 murine melanoma model
Serrano OK, Parrow NL, Violet P-C, Yang J, Zornjak J, Basseville A, et al. Free Radic Biol Med. 2015;87:193–203.
- Mechanisms of Ascorbate-induced cytotoxicity in pancreatic Cancer
Du J, Martin SM, Levine M, Wagner BA, Buettner GR, Wang S, et al. Clin Cancer Res. 2010;16(2):509–20.
- Pharmacological ascorbic acid suppresses syngeneic tumor growth and metastases in hormone-refractory prostate cancer
Pollard HB, Levine MA, Eidelman O, Pollard M. In Vivo. 2010;24(3):249–55.
- Increased tumoral microenvironmental pH improves cytotoxic effect of pharmacologic ascorbic acid in castration-resistant prostate Cancer cells
Li Z, He P, Luo G, Shi X, Yuan G, Zhang B, et al. Front Pharmacol. 2020;11:570939.
- Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy
Chen P, Yu J, Chalmers B, Drisko J, Yang J, Li B, et al. Anti-Cancer Drugs. 2012;23(4):437–44.
- Vitamin C counteracts miR-302/367-induced reprogramming of human breast cancer cells and restores their invasive and proliferative capacity
Ramezankhani B, Taha MF, Javeri A. J Cell Physiol. 2019;234(3):2672–82.
- Vitamin C inhibits metastasis of peritoneal tumors by preventing spheroid formation in ID8 murine epithelial peritoneal Cancer model
Xu Y, Guo X, Wang G, Zhou C. Front Pharmacol. 2020;11:645.
- Vitamin C supplementation had no side effect in non-cancer, but had anticancer properties in ovarian cancer cells
Gregoraszczuk EL, Zajda K, Tekla J, Respekta N, Zdybał P, Such A. Int J Vitam Nutr Res. 2020;3:1–11.
- Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2
Lv H, Wang C, Fang T, Li T, Lv G, Han Q, et al. npj Precis Oncol. 2018;2(1):1.
- Cytotoxic and partial hepatoprotective activity of sodium ascorbate against hepatocellular carcinoma through inhibition of sulfatase-2 in vivo and in vitro
Alyoussef A, Al-Gayyar MMH. Biomed Pharmacother. 2018;103:362–72.
- Preclinical Demonstration of Synergistic Active Nutrients/Drug (AND) Combination as a Potential Treatment for Malignant Pleural Mesothelioma
Volta V, Ranzato E, Martinotti S, Gallo S, Russo MV, Mutti L, et al. PLoS One. 2013;8(3):e58051.
- Selective Ascorbate toxicity in malignant mesothelioma
Ranzato E, Biffo S, Burlando B. Am J Respir Cell Mol Biol. 2011;44(1):108–17.
- Vitamin C kills thyroid cancer cells through ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways via distinct mechanisms
Su X, Shen Z, Yang Q, Sui F, Pu J, Ma J, et al. Theranostics. 2019;9(15):4461–73.
- Vitamin C cytotoxicity and its effects in redox homeostasis and energetic metabolism in papillary thyroid carcinoma cell lines
Tronci L, Serreli G, Piras C, Frau DV, Dettori T, Deiana M, et al. Antioxidants. 2021;10(5):809.
- Vitamin C promotes apoptosis and cell cycle arrest in Oral squamous cell carcinoma
Zhou J, Chen C, Chen X, Fei Y, Jiang L, Wang G. Front Oncol. 2020;10:976.
- H2O2-mediated cytotoxicity of pharmacologic Ascorbate concentrations to neuroblastoma cells: potential role of lactate and ferritin
Deubzer B, Mayer F, Kuçi Z, Niewisch M, Merkel G, Handgretinger R, et al. Cell Physiol Biochem. 2010;25(6):767–74.
- High dose Ascorbate causes both Genotoxic and metabolic stress in Glioma cells
Castro M, Carson G, McConnell M, Herst P. Antioxidants. 2017;6(3):58.
- Current limitations of murine models in oncology for Ascorbate research
Campbell EJ, Dachs GU. Front Oncol. 2014;4:282.
- Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice
Campbell EJ, Vissers MCM, Wohlrab C, Hicks KO, Strother RM, BOzonet SM, et al. Free Radic Biol Med. 2016;99:451–62.
- Anti-cancer effect of pharmacologic ascorbate and its interaction with supplementary parenteral glutathione in preclinical cancer models
Chen P, Stone J, Sullivan G, Drisko JA, Chen Q. Free Radic Biol Med. 2011;51(3):681–7.
- Inhibition of the development of metastases by dietary vitamin C:K3 combination
Taper HS, Jamison JM, Gilloteaux J, Summers JL, Calderon PB. Life Sci. 2004;75(8):955–67.
- High-dose vitamin C enhances cancer immunotherapy
Alessandro Magrì et al. Sci Transl Med. 2020 Feb 26;12(532):eaay8707.
- High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer
Franziska Böttger et al. J Exp Clin Cancer Res. 2021 Oct 30;40(1):343.
- High-Dose Vitamin C: Preclinical Evidence for Tailoring Treatment in Cancer Patients
Manuela Giansanti et al. Cancers (Basel). 2021 Mar 20;13(6):1428.
